EDUCATION AND TRAINING
- 1999: B.Eng in Food Chemistry and Technology, Hanoi University of Technology, Vietnam.
- 2004: M.Sc in Biotechnology, Hanoi University of Technology, Vietnam.
- 2011: Dr. rer. nat in Biochemistry, University of Saarland, Germany.
- 10/2013-1/2014: Visiting research; Expression and Structuralization of Eukaryote protein in Escherichia coli; Infection and Immunity Research Center, Korea Research Institute of Biosciences and Biotechnology (KRIBB), Korea.
- 6-8/2015: Visiting research; Application of Enzyme Cytochrome P450s and Whole-cell biocatalyst in the Transformation of Natural products; University of Saarland, Germany.
- 11/2015-1/2016: Visiting research; Construction of Biosynthetic pathways for Heterologous expression in Escherichia coli and Aspergillus oryzae; University of Bristol, England.
FIELDS OF CURRENT RESEARCH/INTEREST
- Exploitation and recombinant production of natural products from bacteria, fungi and plants.
- Exploitation of native and recombinant enzymes/proteins from microbial, plant and animal resources.
- Application of Enzyme cytochrome P450s
RESEARCH PROJECTS
2016-2018: “Development of a whole-cell biocatalyst for the transformation of sesquiterpene compounds”, Internatonal Foundation for Science (IFS), Sweden; Principal investigator.
2014-2016: “Construction of a P450-based recombinant E. coli whole-cell biocatalyst for the production of new sesquiterpene derivatives”; National Foundation for Sciences and Technology (NAFOSTED); Principal investigator.
2013-2014: “Isolation of Myxobacteria Sorangium cellulosums carrying epothilone gene clusters in Vietnam”; Institute of Biotechnology, Vietnamese Academy of Science and Technology; Principal investigator.
2012-2014: “Study on the production of recombinant lumbrokinase for thrombosis prevention”, Ministry of Science and Technology (MOST)- KC04/11-15 program; Participant member.
2008-2011: “Exploitation of Enzyme cytochrome P450 of the myxobacterium Sorangium cellulosum So ce56”, University of Saarland, Germany; Participant member.
PUBLICATIONS
- Alexander Schifrin, Thuy T. B. Ly, Nils Günnewich, Josef Zapp, Verena Thiel, Stefan Schulz, Frank Hannemann, Yogan Khatri, Rita Bernhardt (2015) Characterization of the Gene Cluster CYP264B1-geoA from Sorangium cellulosum So ce56: Biosynthesis of (+)-Eremophilene and Its Hydroxylation. Chembiochem 16(2):337-44
- Thuy Thi Bich Ly, Bach Duc Nguyen, Frank Hannermann, Rita Bernhardt (2015) Heterologous production of a sesquiterpene in Escherichia coli. Journal of Biology37(1): 91-98
- Thuy Thi Bich Ly, Bach Duc Nguyen, Frank Hannermann, Rita Bernhardt (2014) Cloning, expression and characterization of a terpene cyclase from the myxobacteria Sorangium cellulosum. Journal of Biotechnology 12(4): 723-730
- Vu Thi Bich Ngoc, Ly Thi Bich Thuy, Quyen Dinh Thi (2013) Cloning and expression of Lumbrokinase in Pichia pastoris. National Biotechnology conference, pp 152-155
- Bui Phuong Linh, Do Thi Tuyen, Ly Thi Bich Thuy (2013) Cloning and expression of Lumbrokinase from Lumbricus rubellus in Escherichia coli. National Biotechnology conference, pp 128-132
- Le Dinh Quyen, Ly Thi Bich Thuy, Do Thi Tuyen, Vu Thi Bich Ngoc, Tran Thi Thanh Binh, Quyen Dinh Thi (2013) Collection and classification of some earthworm species with fibrinolytic activity in Vietnam. National Biotechnology conference, pp 436-441
- Thuy T B Ly, Yogan Khatri, Josef Zapp, Michael C Hutter, Rita Bernhardt (2012) CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase. Appl Microbiol Biotechnol 95(1):123-33
- Ly Thi Bich Thuy, Pham Cong Hoat, Nguyen Thi Kim Xuyen, Nguyen Thi Ngoc Dao (2006) Anticoagulant effects of earthworm powder on experimental rabbit. Journal of Medicinal Materials 2 (11): 74-77
- Do Thi Tuyen, Ly Thi Bich Thuy, Nguyen Thi Ngoc Dao (2005) Effect of Vietnamese Morinda citrifolia fruit extract on rat hepatic enzyme metabolism. Journal of Medicinal Materials 4 (10): 28-132
- Ly Thi Bich Thuy, Nguyen Thi Ngoc Dao (2004) Purification and characterization of fibrinolytic enzyme from an earthworm, Perionyx excavatus. Basic problems in researches of life science. 3rd National science conference, pp 173-176
- Ly Thi Bich Thuy, Nguyen Truong Giang, Nguyen Thi Ngoc Dao (2003) Fibrinolytic activity of enzymes extracted from some earthworms found in Vietnam. Basic problems in researches of life science. 2nd National Biotechnology conference, pp 531-533
- Do Thi Tuyen, Nguyen Thai Bieng, Le Thi Thuy Duong, Do Thi Hong Cam, Ta Kim Thach, Ly Thi Bich Thuy, Nguyen Thi Ngoc Dao (2002) Effect of Rotundin sulfat on Cytochrome P450 system of white rat. Conference on Biochemistry, pp 8-17
- Nguyen Thi Ngoc Dao, Do Thi Tuyen, Tran Van Khanh, Do Thi Hong Cam, Le Thi Thuy Duong, Ly Thi Bich Thuy, Ta Kim Thach, Hoang Thi Thanh, Tran Manh Hung, Nguyen Thi Cuc, Hoang Dinh Cau (2002) Effects of Naturenz – a natural compound on the health of patient exposed to A.O/Dioxin. Vietnam-United States scientific conference on human health and environmental effects of agent orange/dioxin, Hanoi, Vietnam, pp 555-563
- Nguyen Truong Giang, Quach Xuan Hinh, Do Thi Tuyen, Le Thi Thuy Duong, Ly Thi Bich Thuy, Tran Thi Chinh, Nguyen Thi Ngoc Dao (2002) Application of a new method to screen and detect mutation point of G6PD deficiency patients in hospital 108. Conference on Biochemistry, pp17- 21
- Do Thi Tuyen, Pham Manh Hoan, Le Thi Thuy Duong, Ta Kim Thach, Hoang Thi Thanh, Ly Thi Bich Thuy, Nguyen Thi Ngoc Dao (2001) Studying on Cytochrome P450 system in intoxicated patients by Trinitrozotoluen. Conference on Biochemistry, pp 71-73
- Ly Thi Bich Thuy, Nguyen Truong Giang, Le Thi Thuy Duong, Nguyen Thi Ngoc Dao (2001) Studying a new method to detect rapidly G6PD deficiency of human blood cells. Conference on Biochemistry, pp 310-315
- Le Thi Thuy Duong, Ly Thi Bich Thuy, Nguyen Thi Ngoc Dao (2001) Purification and immobilization of penicillin acylase from E. coli. International Workshop on Biology, Hanoi, Vietnam, pp 100-104
