2002: MSc. Biochemistry. Institute of Ecology and Biological Resources, Vietnamese Academy of Sciences and Technology
FIELDS OF CURRENT RESEARCH/INTEREST
- Biochemistry of proteins/enzymes and bio-active compounds.
- The effects of different substances and their mode of action in distinct disease models, special studies on inflammation in vitro and vivo (endotoxin-LPS and CASP-Colon Ascendens Stent Peritonitis models).
RESEARCH PROJECTS
2013-2016: Purified and biological activities of protease, polysaccharide from Pseuderanthemum palatiferum (Nees) Radlk. IFS- International foundation for science. Principal investigator
2014-2015: Determination of hyaluronic acid in the aquatic waste and method for extraction. Institute of Biotechnology. Principal investigator
2011-2012: Production of recombinant Bacillus secreted pectinase for cotton processing. KC04-TN06/11-15, Ministry of Science and Technology.Principal investigator
2011-2014: Mechanisms of actions of phytochemicals against Streptococus mutans in biofilms. National Foundation for Sciences and Technology (NAFOSTED). Participant member.
2008-2010: Application of biotechnology to produce chondroitin sulfate from Dasyatis Kuhlii and Carcharhinus Sorrah. Ministry of Agriculture and Rural Development, Vietnam, National Research Program. Participant member.
2008-2010: Application of biotechnology for hydrolysis of cellulose from agar waste. Ministry of Agriculture and Rural Development, Vietnam, National Research Program. Participant member
2007-2008: Screening for new alpha-glucosidase inhibitors from Vietnamse plants for the treatment of diabetes and obesity. Institute of Biotechnology. Principal investigator
2008: Microcirculatory changes during experimental sepsis. German Canadian Collaboration (GECCO). Participant member
2003-2006: Effects of antibiotics on intestinal microcirculation, cytokine release and in vitro vascular reactivity in septic rats. Deutsche Forschungsgemeinschaft (GRK-840), Greifswald University, Germany. Participant member
2002-2004: Study on extraction procedure of flavolignans silymarin and production of biomass from milk thistle sylibum marianum grown in Viet Nam. Ministry of Science and Technology, Vietnam, National Research Program KC.04.17. Participant member
PUBLICATIONS
1.Bac VH, Oanh LTL (2003). Amino acid and mineral contents in the leaf of Pseuderanthemum palatiferum. J Mater Med 8:11–15
EDUCATION AND TRAINING
1994: BSc. Biochemistry. Faculty of Biology, Hanoi University
1/1999-2/1999: Trainee in Biotechnology training course, Singapore.
2002: MSc. Biochemistry. Institute of Ecology and Biological Resources, Vietnamese Academy of Sciences and Technology
2006: Dr. re.med. Faculty of Medicine, Greifswald University, Germany.
03/2008-08/2008: Postdoc. Departments of Pharmacology, Microbiology and Immunology, Dalhousie University, Halifax,Canada
FIELDS OF CURRENT RESEARCH/INTEREST
RESEARCH PROJECTS
2011-2012: Production of recombinant Bacillus secreted pectinase for cotton processing. KC04-TN06/11-15, Ministry of Science and Technology.Principal investigator
2011-2014: Mechanisms of actions of phytochemicals against Streptococus mutans in biofilms. National Foundation for Sciences and Technology (NAFOSTED). Participant member.
2008-2010: Application of biotechnology to produce chondroitin sulfate from Dasyatis Kuhlii and Carcharhinus Sorrah. Ministry of Agriculture and Rural Development, Vietnam, National Research Program. Participant member.
2008-2010: Application of biotechnology for hydrolysis of cellulose from agar waste. Ministry of Agriculture and Rural Development, Vietnam, National Research Program. Participant member
2007-2008: Screening for new alpha-glucosidase inhibitors from Vietnamse plants for the treatment of diabetes and obesity. Institute of Biotechnology. Principal investigator
2008: Microcirculatory changes during experimental sepsis. German Canadian Collaboration (GECCO). Participant member
2003-2006: Effects of antibiotics on intestinal microcirculation, cytokine release and in vitro vascular reactivity in septic rats. Deutsche Forschungsgemeinschaft (GRK-840), Greifswald University, Germany. Participant member
2002-2004: Study on extraction procedure of flavolignans silymarin and production of biomass from milk thistle sylibum marianum grown in Viet Nam. Ministry of Science and Technology, Vietnam, National Research Program KC.04.17. Participant member
PUBLICATIONS
1. Bac VH, Oanh LTL (2003). Amino acid and mineral contents in the leaf of Pseuderanthemum palatiferum. J Mater Med 8:11–15
2. Lehmann C, Bac VH, Pavlovic D, Lustig M, Bohnenstengel S, Heidecke CD, Wendt M, Gründling M (2005). Metronidazol verbessert die intestinale Mikrozirkulation bei septischen Ratten, in: Matschke K, Knaut M, and Jung F (Ed.): Myocardial Microcirculation, Pabst Science Publishers, Lengerich 2005, 141-155.
3. Lehmann C, Bac VH, Pavlovic D, Lustig M, Bohnenstengel S, Maier S, Feyerherd F, Usichenko T, Meissner K, Haase H, Jünger M, Wendt M, Heidecke CD, Gründling M (2006). Metronidazole improves intestinal microcirculation in septic rats independently of bacterial burden. Clinical Hemorheology and Microcirculation, 34:427-438.
4. Pavlovic D, Frieling H, Lauer KS, Bac VH, Richter J, Wendt M, Lehmann C, Usichenko T, Meissner K, and Gründling M (2006). Thermostatic tissue platform for intravital microscopy: “the hanging drop” model. Journal of microscopy – Oxford, 224 (2): 203-10.
5. Lustig M, Bac VH, Pavlovic D, Maier S, Gründling M, Grisk O, Wendt M, Heidecke CD, and Lehmann C (2007). CASP (Colon Ascendens Stent Peritonitis) – a model of sepsis adopted to the rat: physiological, microcirculatory and laboratory changes. Shock, 28 (1): 59-64.
6. Gründling M, Lehmann C, Saeger. D, Bohnenstengel S, Pavlovic. D, Bac. V, Usichenko. T, Meissner. K, Wendt. M, Hung. O, Murphy. M, Whynot. S, Lindequist. U (2008). Response of the rat intestinal microcirculation to experimental endotoxemia is attenuated by ampicillin but not by its derivative KKP723. Clinical Hemorheology and Microcirculation, 38: 163-170.
7. Vo Hoai Bac, Tran Canh Đinh, Le Thi Lan Oanh (2010). Extraction of chondroitin sulfate from Dasyatis Kuhlii and Carcharhinus Sorrah by ETM protease application. Journal of Biotechnology. 8 (3A) : 593-602
8. Vo Hoai Bac, Le Huong Thuy, Le Thi Lan Oanh. 2010. Screening of producing cellulolytic enzyme microorganisms for cellulose hydrolysing from agar waste. Rimf newsletter 15 (1): 20-24. ISSN 1859-2619.
9. Vo Hoai Bac, Đo Ngoc Tu, Tran Canh Dinh, Le Thi Lan Oanh (2010). Extraction of chondroitin sulfate from Dasyatis Kuhlii and Carcharhinus Sorrah by enzyme technology. Rimf newsletter, 16 (4): 26-30. ISSN 1859-2619.
10. Richter J, Zhou J, Pavlovic D, Scheibe R, Bac VH, Helmut J, Hung O, Murphy MF, Whynot S, Lehmann C (2010). Vancomycin and to lesser extent tobramycin have vasomodulatory effects in experimental endotoxemia in the rat. Clinical Hemorheology and Microcirculation 46: 37-49
11. Đo Thi Thu Hang, Vo Hoai Bac, Le Van Truong (2012). Screening and cloning of pectate lyase gene from from Bacillus subtilis isolated in Vietnam. Journal of Biology 34(4):485-492.
12. N.A. Al-Banna, D. Pavlovic, V.H. Bac, K. Utpatelb, E. Janke,J.N. Rippke, M. Borowiak, V. Cerny, A. Spassov, B. Johnston,T.B. Issekutze, C.H. Lehmann (2013). Acute administration of antibiotics modulates intestinal capillaryperfusion and leukocyte adherence during experimental sepsis. International Journal of Antimicrobial Agents 41: 536 – 543.
13. Vo Hoai Bac, Do Thi Thu Hang, Le Trong Tai, Le Van Truong (2013). High level expression of a gene coding for pectate lyase in Bacillus subtilis 168. Journal of Biology 35 (3): 369 – 375.
14. Nguyen Thi Mai Phuong, Vo Hoai Bac, Pham Thi Luong Hang, Hoang Phuong Ha, Tran Thi Nhung (2013). Alpha-mangostin inhibits biofilm formation by Streptococcus mutans UA159. Journal of Biology 35 (3se): 100 -105
15. Le Trong Tai, Đo Thi Thu Hang, Vo Hoai Bac, Le Van Truong (2013). Using recombinant pectate lyase removal of pectin from Raw cotton fabric. National conference of biotechnology. (1): 455-458
16. Nadia Al-Banna, Dragan Pavlovic, Nivin Sharawi, Vo Hoai Bac, Mathis Jaskulski, Claudius Balzer, Stefan Weber, Vladimir Nedeljkov, Christian Lehmann (2014). Combination of dehydroepiandrosterone and orthovanadate administration reduces intestinal leukocyte recruitment in models of experimental sepsis. Microvasc Res;95:82-7
17. Vo Hoai Bac, Tran Thi Hong, Nguyen Thi Mai Phuong, Le Van Truong. (2015). Detection of hyaluronic acid in the aquatic waste and extraction by enzyme technology. J Biol (Accepted)
18. Nguyen Thi Mai Phuong, Vo Hoai Bac, Tran Thi Nhung, Do Hoang Hiep. (2015). Preparation of protein isolates from rice bran. J Biol (Accepted)
19. Phuong Thi Mai Nguyen, Bac Hoai Vo, Nhung Thi Tran, Quyen Dong Van. (2015). Anti-biofilm activity of α-mangostin isolated from Garcinia mangostana L. Zeitschrift für Naturforschung C. (Accepted).